Osteocytic connexin 43 channels affect fracture healing
نویسندگان
چکیده
منابع مشابه
Induced Gating of Connexin 43 Gap Junction Channels
Suppression of gap-junctional communication by various protein kinases, growth factors, and oncogenes frequently correlates with enhanced mitogenesis. The oncogene v -src appears to cause acute closure of gap junction channels. Tyr265 in the COOH-terminal tail of connexin 43 (Cx43) has been implicated as a potential target of v -src , although v -src action has also been associated with changes...
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Bisphosphonates (BPs) have been in use for many years for the treatment of osteoporosis, multiple myeloma, Paget's disease, as well as a variety of other diseases in which there is reduced bone mineral density. Given that bisphosphonates inhibit bone resorption, an important stage of fracture healing; this class of compounds has been widely studied in preclinical models regarding their influenc...
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Introduction: Recent studies have shown that astrocytes play major roles in normal and disease condition of the central nervous system including multiple sclerosis (MS). Molecular target therapy studies in MS have revealed that connexin-43 (Cx43) and Aquaporin-4 (AQP4) contents of astrocytes undergo expression alteration. Fluoxetine had some effects in MS patients unrelated to its known antidep...
متن کاملOsteocytic connexin 43 is not required for the increase in bone mass induced by intermittent PTH administration in male mice
OBJECTIVE To investigate whether osteocytic connexin 43 (Cx43) is required for the bone response to intermittent PTH administration, and whether the connexin is involved in maintaining the bone matrix. METHODS Human PTH(1-34) was injected to adult male mice expressing (Cx43(fl/fl)) or not osteocytic Cx43 (Cx43(fl/fl);DMP1-8kb-Cre) daily (100 µg/kg/d) for 14 days. RESULTS Cx43(fl/fl);DMP1-8k...
متن کاملEvidence for a Protective Effect of Connexin 43 Deficiency in the Development of Osteocytic Osteolysis During Skeletal Unloading
Evidence for a Protective Effect of Connexin 43 Deficiency in the Development of Osteocytic Osteolysis During Skeletal Unloading Shane A. Lloyd [email protected] Alayna E. Loiselle [email protected] Yue Zhang [email protected] Henry J. Donahue [email protected] Division of Musculoskeletal Sciences, Department of Orthopaedics and Rehabilitation Penn State College of Medicine, 500 Unive...
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ژورنال
عنوان ژورنال: Journal of Cellular Physiology
سال: 2019
ISSN: 0021-9541,1097-4652
DOI: 10.1002/jcp.28581